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Allay Therapeutics raises $45M for ongoing Series D; Encoded’s layoffs

Plus, news about Pliant Therapeutics, Blueprint Medicines, Galapagos and Atai: Pain biotech raises $45M: Allay Therapeutics, which is developing non-opioid analgesics pain drugs, held the first close...

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Syngene CEO departs; Lilly and AdvanCell sign radiotherapy partnership

Welcome to Endpoints News’ manufacturing briefs, where we bring you essential news on new builds, collaborations, recalls and more. The CEO of India-based CDMO Syngene, Jonathan Hunt, has left the role...

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Agios’ Pyrukynd succeeds in key trial of rare red blood cell disorder in kids

Agios' blood disease treatment Pyrukynd passed a Phase 3 study in PK deficiency in children who do not regularly receive blood transfusions. The readout arrives after Pyrukynd last year failed to meet ...

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Kennedy is confirmed by Senate as Trump's HHS secretary

The Senate on Thursday confirmed Robert F. Kennedy Jr. as Secretary of Health and Human Services, putting a longtime anti-vaccination advocate at the helm of the nation’s health agencies that monitor...

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Knownwell is betting on in-person weight management care

Knownwell, the Andreessen Horowitz and Flare Capital Partners-backed metabolic health and primary care startup, is adding six locations in the Chicago area. It’s the latest addition to its in-person...

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David Baker lab makes de novo enzymes with AI

The lab of Nobel laureate David Baker keeps pushing the limits of what's possible in making proteins with computers, opening up new possibilities in using AI to make drugs. The latest advance

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Labs fear future funding cuts with Trump administration actions in limbo

A series of actions by President Donald Trump's administration have provoked profound anxiety among academic labs that undergird biomedical research. These policies — including slashing overhead...

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Updated: Moderna earnings: Losses narrow as biotech cuts costs

Moderna is working on restoring investors' faith that its Covid-19 vaccine was not a one-hit-wonder. It also has to show it can get its costs under control. On Friday, the company announced...

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Bristol Myers’ Opdualag stumbles in late-stage resected melanoma trial

Bristol Myers Squibb’s LAG-3/PD-1 targeting immunotherapy Opdualag failed to boost survival in patients with advanced skin cancer in a Phase 3 study, marking the latest flop for an approach that has a...

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David Schenkein resigns from Agios’ board; Moderna hires Roivant exec as...

David Schenkein will step down from Agios Pharmaceuticals’ board of directors at the end of the month "to devote more time to his other commitments," according to its earnings report Thursday. He will...

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How Bain’s $3.3B deal for a centuries-old Japanese pharma came to fruition

About two and a half years before they sealed a $3.3 billion deal, Bain Capital and its life sciences team started courting the leadership of Tanabe Pharma and its parent Mitsubishi Chemical ...

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BioNTech vets raise about $90M in Series A for bispecific immunology research

A new immunology biotech closed its Series A, and it’s backed by investors intricately familiar with the industry. Bambusa Therapeutics said Friday that it raised “approximately” $90 million in the...

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Otsuka makes pipeline changes; Oculis reveals $100M offering

Plus, news about Aardvark’s IPO: Otsuka cuts cancer programs: The drugmaker is stopping development of OPB-111077, an oral STAT inhibitor, for hematological cancers in the US. It also terminated...

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#ASCOGU: Corbus shares dip on mixed Phase 1 solid tumor data for Nectin-4 ADC

Corbus Pharmaceuticals reported encouraging early-stage results for its Nectin-4 targeting ADC in various types of cancer, but a lack of response in certain patients caused shares to slide. The...

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West Pharma loses two glucose device clients but is buoyed by its GLP-1...

West Pharmaceuticals Services’ stock {$WST} tanked by as much as 38% late Thursday after the packaging and delivery system provider said it was ending major contracts with two unnamed glucose...

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Kojin Therapeutics shuts down, citing lack of investor interest and complex...

Kojin Therapeutics, a startup attempting to develop new treatments using programmed cell death, left last month’s JP Morgan Healthcare Conference in a bind. It needed bridge financing to stay afloat...

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Drugmakers plan Trump meeting next week amid health shakeups

Major drugmakers are planning to meet with President Donald Trump next week at the White House as part of the industry’s effort to work with the new administration. The details of the meeting are still...

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ARPA-H chief is out as Trump administration cuts health agencies

Renee Wegrzyn has been let go as the head of a federal agency that pursues ambitious ideas to accelerate biomedical innovation, part of a broad series of ongoing changes being made by the new Trump ...

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J&J to face pivotal hearing over its $8B talc settlement plan

Johnson & Johnson is set to push for confirmation of a bankruptcy plan next week that would settle a vast majority of cases alleging the company’s talc products caused cancer. The controversial...

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NIH, CDC cuts expected as Trump shakeup hits healthcare

The Trump administration’s effort to remake the federal workforce swept through US healthcare agencies on Friday, with wide cuts planned across several major health organizations and hints of more to...

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